Can I flash my ISM300Fx GPS in system?

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Yes, the ISM300Fx can be flashed in system by pulling pin 8 High upon power up. The module will then boot up in flash mode and you can update the firmware over the UART. This pin has a pulldown interanlly so if you do not want to flash in system you can leave this pin floating or pull to ground.

The pin is only used during initial power up.